Minoxidil Sulfate Description
Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. It has been shown to relax norepinephrine contraction and is reported to be a vasodilator. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has been demonstrated to increase tumor permeability.
Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered a vasodilator to promote hair growth in vivo.
Minoxidil Sulfate vs. Minoxidil
Minoxidil is widely used to treat androgenetic alopecia. However, it does not directly promote hair growth itself. Instead, it needs to be converted by sulfotransferase in the hair follicles into its active form—Minoxidil Sulfate—to take effect.
Minoxidil Sulfate Specifications
Product Name |
Minoxidil Sulfate |
CAS Registry Number |
83701-22-8 |
Molecular Formula |
C9H15N5O4S |
Molecular Weight |
289.3 g/mol |
Purity |
≥95% |
Package |
1kg-25kg |
Storage |
Light Sensitive – Protect from Light |
Shelf life |
2 years |
Functions |
Accelerate animal and human hair growth, prevent hair loss, and lower blood pressure |
Minoxidil Sulfate Applications
- Pharmaceutical ingredients of topical medicine effective for hair loss treatment
Reference:
- Buhl, A., et al.: J. Invest. Dermatol., 95, 553 (1990)
- Meisheri, K.D., et al. 1988. J. Pharmacol. Exp. Ther. 245: 751-760.
- Winquist, R.J., et al. 1989. J. Pharmacol. Exp. Ther. 248: 149-156.
- Andersson, K.E., et al.: Pharmacol. Toxicol., 70, 244 (1992)
- Quast, U., et al. 1995. Naunyn Schmiedebergs Arch. Pharmacol. 353: 86-93.
- Black, K.L., et al. 2008. Brain Res. 1227: 198-206.