HA4819 Rapamycin Powder, CAS 53123-88-9

Rapamycin Specifications

Rapamycin Description

Rapamycin is a macrolide compound used to cover coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has an immunosuppressive function in the human body and is particularly useful in preventing kidney transplant rejection. Rapamycin was first evaluated as an antifungal agent but is now studied for its potent immunosuppressive and antiproliferative properties.

Rapamycin is used in clinical settings to prevent rejection in organ transplantation and to treat certain types of cancer.

Rapamycin Applications

• Laboratory research
• Used as pharmaceutical ingredients for anti-rejection therapy for kidney transplantation

FAQs

1. How does Rapamycin work?

Rapamycin works by inhibiting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, thereby regulating cell growth, proliferation, and differentiation. This mechanism is crucial for its roles in immunosuppression and anti-tumor therapy.

2. What are the side effects of Rapamycin?

Common side effects include:

• High blood sugar
• High blood lipid levels
• High blood pressure
• Liver function abnormalities
• Increased risk of infections
• Anemia
• Mouth ulcers

Long-term use may increase the risk of certain severe side effects; therefore, usage should be under medical supervision.

3. How is Rapamycin taken?

The dosage and administration method of Rapamycin vary depending on its use and the individual patient’s condition. It is usually prescribed and managed by a doctor; adjusting the dosage or discontinuing use without medical advice is not recommended.

4. Is Rapamycin suitable for everyone?

Rapamycin is primarily used for specific medical conditions, such as patients undergoing organ transplantation or those with certain types of cancer. Its safety and efficacy need to be evaluated under professional medical guidance. Pregnant and breastfeeding women, as well as individuals with certain medical histories, should use it with caution.

5. Does Rapamycin interact with other medications?

Yes, Rapamycin may interact with various medications, including but not limited to:

• Antibiotics (e.g., Erythromycin)
• Antifungal drugs (e.g., Ketoconazole)
• Antihypertensive medications
• Immunosuppressants

Before using Rapamycin, inform your doctor about all medications you are currently taking to avoid adverse interactions.

6. What are the storage conditions for Rapamycin?

Rapamycin should be stored in a cool, dry, and dark place, avoiding high temperatures and humidity. Specific storage conditions should be referenced from the medication packaging or by consulting a pharmacist.

Reference:

1. Kay JE, et al. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72: 544-549 (1991).
2. Barbet NC, et al. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7(1): 25-42 (1996).
3. Guba M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8(2): 128-135 (2002).
4. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem 282(18): 13395-13401 (2007).